Chinese medicine and diabetic foot ulcers

NewsBot · Apr 17, 2024

Summary and evaluation of randomized controlled trial on Chinese patent medicine in treatment of diabetic foot ulcer
Wen-Ting Song et al
Zhongguo Zhong Yao Za Zhi. 2024 Feb;49(4):1113-1121.

This study systematically collected, analyzed, and evaluated randomized controlled trial(RCT) in the treatment of diabetic foot ulcer(DFU). The aim as provide references for future studies and to enhance the application of clinical evidence. The RCT of DFU treated with Chinese Patent Medicine was obtained and analyzed using the AI-Clinical Evidence Database of Chinese Patent Medicine(AICED-CPM). The analysis was supplemented with data from CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, Cochrane Library, and Web of Science. A total of 275 RCTs meeting the requirements were retrieved, with only 7 of them having a sample size of 200 or more. These trials involved 66 different Chinese patent medicine including 25 oral medications, 24 Chinese herbal injections, and 17 external drugs. Among the 33 different intervention/control designs identified, the most common design was Chinese patent medicine + conventional treatment vs conventional treatment(86 cases, 31.27%). Out of the 275 articles included in the literature, 50 did not provide information on the specific course of treatment(18.18%). A total of 10 counting indicators(with a frequency of 426) and 36 measuring indicators(with a frequency of 962) were utilized. The methodological quality of the RCT for the treatment of DFU with Chinese patent medicine was found to be low, with deficiencies in blind methods, other bias factors, study registration, and sample size estimation. There were noticeable shortcomings in the reporting of allocation hiding and implementation bias(blind method application). More studies should prioritize trial registration, program design, and strict quality control during implementation to provide valuable data for clinical practice and serve as a reference for future investigations.
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NewsBot · Apr 19, 2024

Research progress of traditional Chinese medicine monomer in treating diabetic peripheral neuropathy: A review
Shi Xiaoqin et al
Medicine (Baltimore). 2024 Mar 29;103(13):e37767

Diabetes peripheral neuropathy is one of the most common complications of diabetes. Early symptoms are insidious, while late symptoms mainly include numbness, pain, swelling, and loss of sensation in the limbs, which can lead to disability, foot ulcers, amputation, and so on. At present, the pathogenesis is also complex and diverse, and it is not yet clear. Western medicine treatment mainly focuses on controlling blood sugar and nourishing nerves, but the effect is not ideal. In recent years, it has been found that many drug monomers have shown good therapeutic and prognostic effects in the prevention and treatment of diabetes peripheral neuropathy, and related research has become a hot topic. To understand the specific mechanism of action of traditional Chinese medicine monomers in treatment, this article provides a review of their mechanism research and key roles. It mainly includes flavonoids, phenols, terpenes, saponins, alkaloids, polysaccharides, etc. By nuclear factor-κB (NF-κB), the signaling pathways of adenosine monophosphate-activated protein kinase (AMPK), Nrf2/ARE, SIRT1/p53, etc, can play a role in lowering blood sugar, antioxidant, anti-inflammatory, inhibiting cell apoptosis, and autophagy, promoting sciatic nerve regeneration, and have great potential in the prevention and treatment of this disease. A systematic summary of its related mechanisms of action was conducted, providing ideas for in-depth research and exploration of richer traditional Chinese medicine components, and also providing a relatively complete theoretical reference for clinical research on diabetes peripheral neuropathy treatment.
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Chinese medicine and diabetic foot ulcers

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

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Chinese medicine and diabetic foot ulcers

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

Patent granted for Chinese medicine treatment for "pedopathy"

Chinese Medicine & Acupuncture for Plantar Fasciitis

HPC to regulate Acupuncture, Herbal Medicine and Traditional Chinese

Chinese speaking podiatrist wanted!! new grad welcome

Chinese Foot Binding

Chinese Foot Binding project on Kickstarter

Relationship Between Leg Length and Gestational Diabetes Mellitus in Chinese Pregnant Women

Share This Page

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