This is one for those who, despite NICE guidelines in 2007 suggesting that aqueous cream (inc. E45) should not be used as a leave-on emollient in children with eczema, due to increased risk of irritant reactions, it still remains the most frequently prescribed emollient cream in the UK today for patients with atopic dermatitis.
In a nutshell, this study found that corneocyte maturity were significantly decreased in skin that had been exposed to aqueous cream compared with skin that had not, which is clearly indicative of accelerated skin turnover. Also, transepidermal water loss was higher in aqueous cream treated skin when compared with untreated areas of skin, all of which would be likely to worsen rather than improve symptoms of eczema.
10 June 2011
Br J Dermatol 2011: 164; 1304–1310, 1179-1180