Home Forums Marketplace Table of Contents Events Member List Site Map Register Mark Forums Read

Welcome to the Podiatry Arena forums, for communication between foot health professionals about podiatry and related topics.

You are currently viewing our podiatry forum as a guest which gives you limited access to view all podiatry discussions and access our other features. By joining our free global community of Podiatrists and other interested foot health care professionals you will have access to post podiatry topics (answer and ask questions), communicate privately with other members (PM), upload content, view attachments, receive a weekly email update of new discussions, earn CPD points and access many other special features. Registered users do not get displayed the advertisments in posted messages. Registration is fast, simple and absolutely free so please, join our global Podiatry community today!

If you have any problems with the registration process or your account login, please contact contact us.


Genetic marker for posterior tibial tendinopathy

Submit Thread >  Submit to Digg Submit to Reddit Submit to Furl Submit to Del.icio.us Submit to Google Submit to Yahoo! This Submit to Technorati Submit to StumbleUpon Submit to Spurl Submit to Netscape  < Submit Thread
Thread Tools Display Modes
Old 2nd May 2012, 05:13 PM
NewsBot's Avatar
NewsBot NewsBot is offline
The Admin that posts the news.
Join Date: Jan 2006
Location: The Zoo, where all good monkeys should be
Posts: 20,345
Join Date: Jan 2006
Marketplace reputation 53% (0)
Thanks: 23
Thanked 793 Times in 642 Posts
Default Genetic marker for posterior tibial tendinopathy

Podiatry Arena members do not see these ads
MMP-8 polymorphism is genetic marker to tendinopathy primary posterior tibial tendon.
Godoy-Santos A, Ortiz RT, Junior RM, Fernandes TD, Santos MC.
Scand J Med Sci Sports. 2012 Apr 9.

Posterior tibial tendon is particularly vulnerable and is responsible for much morbidity in sportspersons. Some patients have a predisposition without a clinically recognized cause, suggesting that individual characteristics, inclusive genetic inheritance, play an important role in tendinopathy. Matrix metalloproteinase (MMP)-8 is a proteinase capable of degrading a large amount of extracellular proteins, and influence degradation and remodeling of collagen. To determine whether the -799 polymorphism in the promoter of MMP-8 gene is associated with tendinopathy in posterior tibial tendon, 50 patients undergoing surgical procedures and anatomopathological diagnosis of degenerative lesions of the posterior tibial tendon and 100 control patients with posterior tibial tendon integrity and without signs of degeneration in magnetic resonance imaging were evaluated for the -799 MMP-8 polymorphism. There was a significant difference in the presence of the different alleles (P = 0.001) and genotype (P = 0.003) between the control group and the test group for the MMP-8 gene. The polymorphism at position -799 of the gene for MMP-8 is associated with tendinopathy primary posterior tibial tendon in the population studied. The results suggest that individuals with the T allele are at greater risk of developing tendinopathy.
Reply With Quote
Sponsored Links
Old 2nd May 2012, 05:44 PM
Admin2's Avatar
Admin2 Admin2 is offline
Join Date: May 2005
Location: Cyberspace
Posts: 4,565
Join Date: May 2005
Marketplace reputation 0% (0)
Thanks: 16
Thanked 147 Times in 130 Posts
Default Re: Genetic marker for posterior tibial tendinopathy

Related Threads:
Genetic component to achilles tendon pathology
Reply With Quote

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts
vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Translate This Page

Similar Threads
Thread Thread Starter Forum Replies Last Post
posterior tibial nerve block srd Foot Surgery 39 16th November 2014 03:08 PM
Posterior tibial edema sign in posterior tibial tendon dysfunction NewsBot Biomechanics, Sports and Foot orthoses 1 4th February 2011 09:53 PM
MBT shoes - posterior tibial tendon RSSFeedBot Foot Health Forum 0 31st December 2010 06:00 PM
Posterior tibial tendon dysfunction robcox Biomechanics, Sports and Foot orthoses 37 3rd November 2009 04:11 PM
Prognosis for Posterior Tibial Tendonosis MarkC78 Biomechanics, Sports and Foot orthoses 9 23rd December 2008 08:25 PM

New To Site? Need Help?

Finding your way around:

Browse the forums.

Search the site.

Browse the tags.

Search the tags.

All times are GMT -7. The time now is 04:26 PM.