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From the 2012 ADA Mtg: Serum Magnesium Levels Are Significantly Correlated with the Severity of Inflammation in Patients with Diabetic Foot
SALIM OZENC, SIRZAT YESILKAYA, MUSTAFA CAKAR, EROL ARSLAN, SEREF DEMIRBAS, BAYRAM KOÇ, KENAN SAGLAM
Hypomagnesemia is not an uncommon finding in patients with uncontrolled diabetes mellitus. It is associated with abnormal platelet action and the development of neuropathy, both of which are risk factors for the evolution of ulcers of the feet. A lately suggested data from animal studies shows that during chronic hypomagnesemia, loss of neutral endopeptidase activity contributes to neutrophil activation. In another, high CRP levels were found associted with lower magnesium levels in healthy groups. We aimed to investigate the correlation between serum magnesium levels and indicators of inflammation in diabetic foot patients.
Our study was made on the total of 88 patients; 57 diabetic foot patients and 31 controls. Median age of patient and control groups was 64 and 51, respectively. 25.8 % (n = 7) of controls and 17.5 % (n=10) of patient group were female. Wagner grade of the patient’s foot ulcers were grade 2 on 18 patients and grade 1, 3 and 4 on each 13 patients. Serum magnesium levels of diabetic foot patients (median:1,92 mmol/l) were significantly lower than controls (median:2.1 mmol/l) (p<0.05). Sedimentation levels of diabetic foot ulcer patients (median: 38 mm/hr) were significantly higher than controls (median: 14 mm/hr)(p<0.05). Serum CRP levels of diabetic foot patients (median: 18.0 mg/l) were significantly higher than controls (median: 13.8 mg/l)(p<0.05). On Pearson correlation analysis, there was a significant negative correlation between serum magnesium levels and serum CRP levels of the patient group (p<0.05).
Serum magnesium depletion is present and shows a relationship with development of ulcers in subjects with type 2 diabetes. It has lately been proposed that severe hypomagnesemia is associated with low grade inflammation in metabolic syndrome and cardiovascular inflammation. In the literature, to our knowledge, our study is the first to say that serum magnesium levels are significantly associated with serum CRP levels in diabetic foot patients