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The Use of a Collagen Bilayer Matrix and Risk Factors for Amputation

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Old 13th October 2010, 03:45 PM
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Default The Use of a Collagen Bilayer Matrix and Risk Factors for Amputation

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Functional Limb Salvage in the Diabetic Patient: The Use of a Collagen Bilayer Matrix and Risk Factors for Amputation.
Iorio ML, Goldstein J, Adams M, Steinberg J, Attinger C.
Plast Reconstr Surg. 2010 Oct 8. [Epub ahead of print]
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BACKGROUND: The diabetic foot ulcer presents a therapeutic challenge with a high rate of limb infection and extremity amputation. Adequate debridement and stable coverage of exposed structures is paramount to preserving limb length. We reviewed our use of a collagen bilayer matrix in the diabetic population for the preservation of functional limb length. Salvage rates were stratified with patient comorbidities of severe peripheral arterial disease and/or persistent infection.

METHODS: A retrospective review was performed of all consecutive patients that underwent application of Integra by the senior authors (JSS, CEA) for lower extremity salvage between January 2004 and December 2008.

RESULTS: 105 patients with 121 separate wounds were analyzed. Patients ranged from 22 to 80 (mean 58) years-old, and the average wound size was 25.9 cm in the diabetic population. Average follow up was 325 days, and average number of operations pre-closure was 1.28. In the diabetic population, of the 59 patients identified as low-risk for amputation, 10 (17%) progressed to amputation. Of the 28 patients identified as high-risk for amputation, 15 (54%) progressed to amputation. In the non-diabetics, 31 patients were classified as low-risk for amputation, and 1 (3%) went on to an amputation.

CONCLUSIONS: The use of a collagen bilayer matrix appears to be a viable option for reconstruction and stable closure in the diabetic patient at low-risk for amputation, with risk based on available blood supply and evidence of infection. However, in the diabetic patient at high-risk for amputation, the rate of salvage may not be improved with the use of Integra.
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Old 22nd July 2013, 06:31 AM
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Default Re: The Use of a Collagen Bilayer Matrix and Risk Factors for Amputation

Ease of Use, Safety, and Efficacy of Integra Bilayer Wound Matrix in the Treatment of Diabetic Foot Ulcers in an Outpatient Clinical Setting
A Prospective Pilot Study

Min Yao, Khaled Attalla, Yanhan Ren, Michael A. French, Vickie R. Driver
J Am Podiatr Med Assoc 103(4): 274–280, 2013
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Background: Integra bilayer wound matrix (IBWM) is a bilayer skin replacement system composed of a dermal regeneration layer and a temporary epidermal layer. It is used to treat various types of deep, large wounds via an inpatient procedure in an operating room. We sought to determine ease of use and effectiveness of IBWM in an outpatient clinical setting when treating diabetic foot ulcers. In addition, no epidermal autografting was performed in conjunction with the IBWM after silicone release, as is common in the inpatient setting.

Methods: This 12-week, single-arm, prospective pilot study was conducted in three outpatient clinics. Weekly evaluations included monitoring the wound for signs of infection during the 12-week follow-up phase.

Results: Eleven patients with diabetic foot ulcers who met the inclusion and exclusion criteria were enrolled. One patient was discontinued from the study owing to noncompliance leading to a serious adverse event. Therefore, ten patients who received the study intervention were included in the per-protocol population reported herein. The mean patient age was 60.6 years, with an average 11-year history of diabetes mellitus. Each ulcer was located on the plantar aspect of the foot. No infection was reported during the study. Patients treated with IBWM showed progressive wound healing over time: the greatest mean wound reduction was approximately 95% in week 12. Seven of ten patients (70%) achieved complete wound closure by week 12. No recurrent ulcers were reported during follow-up.

Conclusions: These results are consistent with the hypothesis that IBWM is easy to use, safe, and effective when used on diabetic foot ulcers in an outpatient clinical setting without the secondary procedure of autografting for closure.
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