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Laser treatment for nail fungus

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  #571  
Old 5th June 2015, 11:35 PM
eanna eanna is offline
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Default Re: Laser treatment for nail fungus

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Hi Newsouth ,
Following on from your post last year..." Awaiting for mine ...." Has it arrived and if so how are you getting on with ? Are you treating just nail problems with it ?
Cheers Eanna
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  #572  
Old 12th August 2016, 03:07 AM
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Default Re: Laser treatment for nail fungus

I have a quick question about the various nail lasers. I'm trying to understand if any of the wavelengths used in the various lasers could potentially increase the risk of cancer, in particular, skin cancer.

I have not seen this discussed anywhere. I'm wondering how you would answer a patient if they asked you this question?

When a product is approved by the FDA or given CE mark, has the laser company been required to undertake studies that demonstrate there is no cancer risk?
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  #573  
Old 12th August 2016, 03:57 AM
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Suzannethefoot Suzannethefoot is offline
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Default Re: Laser treatment for nail fungus

Laser treatment cannot be carried out on anyone who has had cancer of any type within a year, and not at all on anyone who has had skin cancer. If the patient has sunburn, then the treatment cannot be carried out until it has gone completely.

I don't think we have to worry about the laser causing cancer, as long as guidelines are followed.

I would be very interested if anyone has evidence to the contrary though!
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  #574  
Old 16th August 2016, 12:41 PM
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Default Re: Laser treatment for nail fungus

Treating onychomycosis with the short-pulsed 1064-nm-Nd:YAG laser: results of a prospective randomized controlled trial.
Karsai S et al
J Eur Acad Dermatol Venereol. 2016 Aug 13
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BACKGROUND:
The role of the short-pulsed 1064-nm-Nd:YAG laser in treating onychomycosis has been the subject of controversial discussion ever since it received FDA approval in 2010. Research to date provides no valid conclusions supporting its use from an evidence-based perspective.
OBJECTIVE:
In this prospective randomized controlled pilot study, we analysed the effect of the short-pulsed 1064-nm-Nd:YAG laser on the rate of mycological remission and clinical improvement after excluding relevant confounders with regard to our previous studies.
PATIENTS AND METHODS:
Twenty patients with a total of 82 mycotic toenails were randomized to the treatment group (short-pulsed 1064-nm-Nd:YAG laser) or control group (no laser treatment). We conducted four laser treatments at 4- to 6-week intervals. In both groups, a local antimycotic agent was applied to the sole of the foot, the area between the toes and the skin directly surrounding the nails. The primary endpoint was complete remission of the onychomycosis after 12 months (fungal culture and histology); secondary endpoints included clinical improvement (Onychomycosis Severity Index, OSI) and the occurrence of pain or other adverse events.
RESULTS:
Mycological remission was not achieved in either study group. A comparison of both groups yielded no difference in the OSI score, both at the beginning of the trial (P = 0.9873) and after 12 months (P = 0.4317). In the treatment group, the OSI score worsened by a mean 2.0 points, and in the control group, by a mean 3.5 points. On a visual analogue scale (0 = 'no pain' to 10 = 'most intense pain'), pain in the treatment group was indicated at a mean score of five. Other adverse events were not reported.
CONCLUSIONS:
The short-pulsed 1064-nm-Nd:YAG laser shows no long-term efficacy as a monotherapy. Its role as an adjuvant therapy should be investigated in upcoming trials.
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  #575  
Old 24th August 2016, 02:21 PM
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Default Re: Laser treatment for nail fungus

Evaluation of Nd:YAG laser device efficacy on onychomycosis: a case series of 30 patients.
Helou J et al
Mycoses. 2016 Jan;59(1):7-11.
Quote:
Until recently, pharmacologic molecules have been the only available treatments for onychomycosis. Laser treatments were introduced for recurrent or resistant cases or in patients in whom oral treatments are contra-indicated. Some devices were approved by the Food and Drug Administration (FDA). Neodymium yttrium aluminium garnet (Nd:YAG) is used for onychomycosis as a short-pulse or a long-pulse system. We aim to evaluate the efficacy of the short-pulse Nd:YAG in treating onychomycosis, its side effects, cure rates, and 12-month recurrence rates. Efficacy was evaluated based on a subjective measure of patient satisfaction on a scale from 1 to 10, and an objective measure based on the results of the mycologic cultures. Medical records of 30 patients were reviewed. Ages ranged from 22 to 85, with a mean of 44. Mycologic cure at 12 months was not achieved in 5 patients (16.67%) who had received laser treatment. None of these patients showed any signs of clinical improvement. Twenty patients (66.67%) were completely cured at 12 months, with corroborating negative mycologic cultures. The remaining five patients (16.67%) had discordance between their clinical cure status and their mycologic cultures. Side effects were reported by 7 patients out of 30 (33%): pain within 48 hours of the treatment session, burning sensation in the treated nail bed area. Our primary end point of negative mycologic cultures at 12 months was seen in 24 out of 30 (80%) of our patients. Similar culture cure rates have not been reported before, not even with systemic treatments with oral antifungals. However, few limitations should warrant us (False-negative results in fungal cultures; time limitation; sample size?). Still, we propose that this alternative should be offered for patients in whom antifungals are contraindicated or for patients previously treated, but not cured by oral antifungals, and in elderly and polymedicated patients.
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