Home Forums Marketplace Table of Contents Events Member List Site Map Register Mark Forums Read



Welcome to the Podiatry Arena forums, for communication between foot health professionals about podiatry and related topics.

You are currently viewing our podiatry forum as a guest which gives you limited access to view all podiatry discussions and access our other features. By joining our free global community of Podiatrists and other interested foot health care professionals you will have access to post podiatry topics (answer and ask questions), communicate privately with other members (PM), upload content, view attachments, receive a weekly email update of new discussions, earn CPD points and access many other special features. Registered users do not get displayed the advertisments in posted messages. Registration is fast, simple and absolutely free so please, join our global Podiatry community today!

If you have any problems with the registration process or your account login, please contact contact us.


Tags: , , ,

Platelet rich plasma and diabetic foot ulcer healing

Reply
Submit Thread >  Submit to Digg Submit to Reddit Submit to Furl Submit to Del.icio.us Submit to Google Submit to Yahoo! This Submit to Technorati Submit to StumbleUpon Submit to Spurl Submit to Netscape  < Submit Thread
 
Thread Tools Display Modes
  #31  
Old 10th December 2014, 01:13 AM
NewsBot's Avatar
NewsBot NewsBot is offline
The Admin that posts the news.
 
About:
Join Date: Jan 2006
Location: The Zoo, where all good monkeys should be
Posts: 16,630
Join Date: Jan 2006
Marketplace reputation 53% (0)
Thanks: 17
Thanked 683 Times in 548 Posts
Default Re: Platelet rich plasma and diabetic foot ulcer healing

Podiatry Arena members do not see these ads
This clinical trial was just registered:
A Prospective, Randomized Clinical Trial of ECLIPSE PRP™ Wound Biomatrix in Non-Healing Diabetic Foot Ulcers
Quote:
A prospective, randomized, controlled, clinical study to establish clinical based evidence of Eclipse PRP™ and compare its performance with the usual and customary practice for the treatment of Wagner 1 or 2 DFUs.
Thread Starter
Reply With Quote
Sponsored Links
  #32  
Old 24th January 2015, 04:02 PM
NewsBot's Avatar
NewsBot NewsBot is offline
The Admin that posts the news.
 
About:
Join Date: Jan 2006
Location: The Zoo, where all good monkeys should be
Posts: 16,630
Join Date: Jan 2006
Marketplace reputation 53% (0)
Thanks: 17
Thanked 683 Times in 548 Posts
Default Re: Platelet rich plasma and diabetic foot ulcer healing

Case series of patients with chronic foot ulcers treated with autologous platelet-rich plasma.
Yotsu RR, Hagiwara S, Okochi H, Tamaki T.
J Dermatol. 2015 Jan 23.
Quote:
Treatment for patients with chronic wounds is entering a new era, and autologous platelet-rich plasma (PRP) is among the most promising treatments. PRP contains a concentration of platelets obtained by centrifuging the patient's blood. Because it contains fibrin and high concentrations of growth factors, PRP is known to promote wound healing. In this study, we present five patients with chronic foot ulcers successfully treated with PRP in our institution. The patients had various underlying diseases: diabetes (n = 2), peripheral arterial disease (n = 1), both diabetes and peripheral arterial disease (n = 1), and cutaneous polyarteritis nodosa (n = 1). Also, we provide a description of PRP's mechanisms, advantages, and limitations.
Thread Starter
Reply With Quote
  #33  
Old 28th February 2015, 03:08 PM
NewsBot's Avatar
NewsBot NewsBot is offline
The Admin that posts the news.
 
About:
Join Date: Jan 2006
Location: The Zoo, where all good monkeys should be
Posts: 16,630
Join Date: Jan 2006
Marketplace reputation 53% (0)
Thanks: 17
Thanked 683 Times in 548 Posts
Default Re: Platelet rich plasma and diabetic foot ulcer healing

Treatment of a non-healing diabetic foot ulcer with platelet-rich plasma.
Suresh DH, Suryanarayan S, Sarvajnamurthy S, Puvvadi S
J Cutan Aesthet Surg. 2014 Oct-Dec;7(4):229-31
Quote:
Lower extremity ulcers and amputations are an increasing problem among individuals with diabetes. Among diabetes mellitus-related complications, foot ulceration is the most common, affecting approximately 15% of diabetic patients during their lifetime. The pathogenesis of diabetic ulcer is peripheral sensory neuropathy, calluses, oedema and peripheral vascular disease. Diabetic ulcer is managed by adequate control of infections and blood sugar levels, surgical debridement with various dressings and off loading of the foot from pressure. In spite of these standard measures, some recalcitrant non-healing ulcers need additional growth factors for healing. Autologous platelet-rich plasma is easy and cost-effective method in treating diabetic ulcers as it provides necessary growth factors which enhance healing.
Thread Starter
Reply With Quote
  #34  
Old 20th March 2015, 09:54 PM
NewsBot's Avatar
NewsBot NewsBot is offline
The Admin that posts the news.
 
About:
Join Date: Jan 2006
Location: The Zoo, where all good monkeys should be
Posts: 16,630
Join Date: Jan 2006
Marketplace reputation 53% (0)
Thanks: 17
Thanked 683 Times in 548 Posts
Default Re: Platelet rich plasma and diabetic foot ulcer healing

Effectiveness of Platelet-Rich Plasma to Enhance Healing of Diabetic Foot Ulcers in Patients With Concomitant Peripheral Arterial Disease and Critical Limb Ischemia
Nikolaos Kontopodis et al
International Journal of Lower Extremity Wounds March 20, 2015
Quote:
We sought to investigate the effect of autologous platelet-rich plasma (PRP) on the healing rate of diabetic foot ulcers in patients with diabetes and concomitant peripheral arterial disease (PAD). Diabetic patients with foot ulceration presenting with PAD who were treated with local growth factors in a single center, during a 24-month period from May 2009 to April 2011, were retrospectively reviewed. Based on the severity of PAD, subjects were divided into groups A (Fontaine classification stages I, IIa, and IIb) and B (Fontaine classification stages III and IV), with those included in the latter being considered to suffer from critical limb ischemia (CLI). End points of the analysis were clinical improvement, limb salvage, and amputation rate. Outcome was compared between groups A and B. Overall, 72 patients were evaluated, 30 with CLI. Ulcer area reduction >50% was observed in 58/72 patients while reduction >90% was achieved in 52/72 patients. There were 14 (19%) major and minor amputations, whereas the limb salvage rate was 89%. This variable was significantly different between groups A and B (100% vs 73%, P < .001), as is rate of reduction in ulcer area >90% (83% vs 56%, P = .02). Reduction of ulcer area >50% was observed in the majority of patients in both groups (group A 86% vs group B 73%, P = .23). In conclusion, PRP could serve as a useful adjunct during management of diabetic foot ulcers even in diabetic patients with unreconstructable arterial disease.
Thread Starter
Reply With Quote
  #35  
Old 10th April 2015, 06:40 PM
NewsBot's Avatar
NewsBot NewsBot is offline
The Admin that posts the news.
 
About:
Join Date: Jan 2006
Location: The Zoo, where all good monkeys should be
Posts: 16,630
Join Date: Jan 2006
Marketplace reputation 53% (0)
Thanks: 17
Thanked 683 Times in 548 Posts
Default Re: Platelet rich plasma and diabetic foot ulcer healing

Topical Platelet-Derived Growth Factor vs Placebo Therapy of Diabetic Foot Ulcers Offloaded With Windowed Casts: A Randomized, Controlled Trial.
Ma C, Hernandez MA, Kirkpatrick VE, Liang LJ, Nouvong AL, Gordon II
Wounds. 2015 Apr;27(4):83-91.
Quote:
OBJECTIVE:
This study sought to compare the efficacy of topical platelet derived growth factor (Regranex, Smith and Nephew, London, UK) (test group) to placebo (control group) in treating diabetic foot ulcers. All subjects had a short leg walking cast with a window fashioned in the cast over the site of the ulcer.
METHODS:
Forty-six subjects were randomized (double-blind) 1:1 to the test or control group and treated for up to 4 months. Subjects had Wagner grade I ulcers with wound area of 1 cm2 to 16 cm2 without severe peripheral arterial disease, osteomyelitis, or any infection requiring antibiotics. Study medication was applied daily and casts changed approximately every 14 days.
RESULTS:
Of the 46 subjects randomized, 38 either healed or completed 16 weeks of therapy without healing. Eight subjects dropped out prior to 16 weeks. Based on intention-to-treat, 12 of 23 (52%) test group subjects healed before 16 weeks compared to 13 of 23 (57%) control group subjects (not significant). Regression analysis demonstrated that slower healing was associated with larger initial wound size (hazard radio [HR] = 0.997, 95% confidence interval [CI]: 0.995-1.00, P = 0.028) and excessive wound drainage (HR = 0.346, 95% CI: 0.126-0.948, P = 0.039). Excluding the patients who dropped out, 25 of 38 (66%) subjects healed by 4 months. Three additional subjects healed with casts that were worn longer than 4 months, for an overall rate of 74% at 9 months. Five subjects developed cast burns, and 3 patients required amputation.
CONCLUSION:
Topical platelet derived growth factor does not appear to significantly improve healing of Wagner grade I diabetic foot ulcers that are treated by offloading with a short leg walking cast. Excellent healing rates may be achieved with casting alone.
Thread Starter
Reply With Quote
  #36  
Old 19th April 2015, 02:33 PM
NewsBot's Avatar
NewsBot NewsBot is offline
The Admin that posts the news.
 
About:
Join Date: Jan 2006
Location: The Zoo, where all good monkeys should be
Posts: 16,630
Join Date: Jan 2006
Marketplace reputation 53% (0)
Thanks: 17
Thanked 683 Times in 548 Posts
Default Re: Platelet rich plasma and diabetic foot ulcer healing

Topical Platelet-Derived Growth Factor vs Placebo Therapy of Diabetic Foot Ulcers Offloaded With Windowed Casts: A Randomized, Controlled Trial
Christine Ma, MD; Michael A. Hernandez, OT; Vincent E. Kirkpatrick, MD; Li-Jung Liang, PhD; Aksone L. Nouvong, DPM; Ian L. Gordon, MD, PhD
WOUNDS. 2015;27(4):83-91.
Quote:
Objective. This study sought to compare the efficacy of topical platelet derived growth factor (Regranex, Smith and Nephew, London, UK) (test group) to placebo (control group) in treating diabetic foot ulcers. All subjects had a short leg walking cast with a window fashioned in the cast over the site of the ulcer.
Methods. Forty-six subjects were randomized (double-blind) 1:1 to the test or control group and treated for up to 4 months. Subjects had Wagner grade I ulcers with wound area of 1 cm2 to 16 cm2 without severe peripheral arterial disease, osteomyelitis, or any infection requiring antibiotics. Study medication was applied daily and casts changed approximately every 14 days.
Results. Of the 46 subjects randomized, 38 either healed or completed 16 weeks of therapy without healing. Eight subjects dropped out prior to 16 weeks. Based on intention-to-treat, 12 of 23 (52%) test group subjects healed before 16 weeks compared to 13 of 23 (57%) control group subjects (not significant). Regression analysis demonstrated that slower healing was associated with larger initial wound size (hazard radio [HR] = 0.997, 95% confidence interval [CI]: 0.995-1.00, P = 0.028) and excessive wound drainage (HR = 0.346, 95% CI: 0.126-0.948, P = 0.039). Excluding the patients who dropped out, 25 of 38 (66%) subjects healed by 4 months. Three additional subjects healed with casts that were worn longer than 4 months, for an overall rate of 74% at 9 months. Five subjects developed cast burns, and 3 patients required amputation.
Conclusion. Topical platelet derived growth factor does not appear to significantly improve healing of Wagner grade I diabetic foot ulcers that are treated by offloading with a short leg walking cast. Excellent healing rates may be achieved with casting alone
Thread Starter
Reply With Quote
  #37  
Old 3rd May 2015, 01:00 PM
NewsBot's Avatar
NewsBot NewsBot is offline
The Admin that posts the news.
 
About:
Join Date: Jan 2006
Location: The Zoo, where all good monkeys should be
Posts: 16,630
Join Date: Jan 2006
Marketplace reputation 53% (0)
Thanks: 17
Thanked 683 Times in 548 Posts
Default Re: Platelet rich plasma and diabetic foot ulcer healing

Effectiveness and Efficiency of Platelet Rich Plasma in the Treatment of Diabetic Ulcers.
Cobos R, Aizpuru F, Parraza N, Anitua E, Orive G.
Curr Pharm Biotechnol. 2015;16(7):630-634.
Quote:
"There is a growing body of evidence suggesting that wound healing in chronic diabetic foot ulcers is growth factor dependent, and that the therapeutic delivery of these growth factors to wounds topically, has the potential ability to accelerate wound healing in conjunction with conventional wound care". There is, however, confusion about the utility of platelet rich plasma because the studies that have evaluated them use a wide range of products (different platelet and leukocyte concentrations, different techniques and frequencies of application, very heterogeneous simple, and different endpoints) making almost impossible to compare data and draw conclusions. In this study, we have analyzed the different platelet rich plasma products from a new perspective: cost-efficiency. According to our data, we observe that platelet rich plasma is a cost-effective option that allows faster healing of ulcers, and that should be taken into account in patients with long evolution ulcers.
Thread Starter
Reply With Quote
  #38  
Old 29th May 2015, 05:25 PM
NewsBot's Avatar
NewsBot NewsBot is offline
The Admin that posts the news.
 
About:
Join Date: Jan 2006
Location: The Zoo, where all good monkeys should be
Posts: 16,630
Join Date: Jan 2006
Marketplace reputation 53% (0)
Thanks: 17
Thanked 683 Times in 548 Posts
Default Re: Platelet rich plasma and diabetic foot ulcer healing

The growing evidence for the use of Platelet-Rich Plasma on diabetic chronic wounds: A review and a proposal for a new standard care.
Picard F, Hersant B, Bosc R, Meningaud J
Wound Repair Regen. 2015 May 28
Quote:
Non-healing chronic wounds and exposed tendons, bones and joints are very challenging to cure specially for diabetic patients. Plastic surgeons have a new weapon to enhance wound healing with the use of autologous growth factors. Recently, the process of fabrication of Platelet-rich plasma has been simplified. The goal of this literature review is to summarize the evidenced-based body of knowledge regarding the treatment of diabetic chronic wounds by Platelet-rich plasma. A PubMed and Cochrane search (1978 to 2015) was performed and all studies assessing the clinical effect of Platelet-rich plasma on the healing of diabetic chronic wounds were included. The screening retrieved 7555 articles and 12 studies were included. On 6 randomized studies included, 5 found significant benefits for the use of Platelet-rich plasma on diabetic chronic foot ulcers and the sixth randomized study did not publish a statistical analysis but found favorable outcomes. The 2 other controlled studies included found significant benefits regarding the healing rate and the 4 uncontrolled studies included showed high rates of healing with the adjunction of Platelet-rich plasma. Regarding the method of use, Platelet-rich plasma was applied on the wound as a gel twice a week (41.7% of studies) or once a week (33.3% of studies). In conclusion, 87.5% of controlled studies found a significant benefit for the adjunction of Platelet-rich plasma to treat chronic diabetic wounds. As PRP may be beneficial, we suggest using PRP on diabetic ulcers which remain unhealed after standard treatment.
Thread Starter
Reply With Quote
  #39  
Old 30th July 2015, 06:34 PM
NewsBot's Avatar
NewsBot NewsBot is offline
The Admin that posts the news.
 
About:
Join Date: Jan 2006
Location: The Zoo, where all good monkeys should be
Posts: 16,630
Join Date: Jan 2006
Marketplace reputation 53% (0)
Thanks: 17
Thanked 683 Times in 548 Posts
Default Re: Platelet rich plasma and diabetic foot ulcer healing

The Effect of Autologous Platelet-Rich Gel on the Dynamic Changes of the Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 Expression in the Diabetic Chronic Refractory Cutaneous Ulcers.
Li L, Chen D, Wang C, Liu G, Ran X.
Diabetes Res. 2015;2015:954701.
Quote:
Aim. To investigate the dynamic changes on the expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in the diabetic chronic refractory cutaneous ulcers after the autologous platelet-rich gel (APG) treatment.
Methods. The study was developed at the Diabetic Foot Care Centre, West China Hospital. The granulation tissues from the target wounds were taken before and within 15 days after APG application. The expression of MMP-2 and TIMP-2 as well as transforming growth factor-β1 (TGF-β1) in the granulation tissue was detected by q TR-PCR and IHC. The relationship between the expression level of MMP-2 and TIMP-2 and their ratio and that of TGF-β1 was analyzed.
Results. The expression of MMP-2 (P < 0.05) was suppressed, and the expression of TIMP-2 (P < 0.05) was promoted, while the ratio of MMP-2/TIMP-2 (P < 0.05) was decreased after APG treatments. The expression of TGF-β1 had negative correlation with the ratio of MMP-2/TIMP-2 (P < 0.05) and positive correlation with the expression of TIMP-2 (P < 0.05).
Conclusions. APG treatment may suppress the expression of MMP-2, promoting that of the TIMP-2 in the diabetic chronic refractory cutaneous wounds. TGF-β1 may be related to these effects.
Thread Starter
Reply With Quote
Reply



Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts
vB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Translate This Page

Similar Threads
Thread Thread Starter Forum Replies Last Post
Platelet Rich Plasma for plantar fasciitis NewsBot Biomechanics, Sports and Foot orthoses 31 19th August 2015 06:00 PM
Platelet-Rich Plasma for Achilles tendon pain srfoot General Issues and Discussion Forum 60 7th August 2015 08:12 PM
Platelet Rich Plasma for Musculoskeletal Conditions NewsBot Biomechanics, Sports and Foot orthoses 41 17th June 2015 10:06 PM
Platelet rich plasma for fractures NewsBot Biomechanics, Sports and Foot orthoses 1 9th November 2012 02:34 PM
Ankle exercises and diabetic foot ulcer healing NewsBot Diabetic Foot & Wound Management 0 30th October 2010 02:31 PM


New To Site? Need Help?

Finding your way around:

Browse the forums.

Search the site.

Browse the tags.

Search the tags.


All times are GMT -7. The time now is 05:08 AM.