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Topical Treatment of Tinea Pedis Using 6% Coriander Oil in Unguentum Leniens: A Randomized, Controlled, Comparative Pilot Study
Beikert F.C. · Anastasiadou Z. · Fritzen B. · Frank U. · Augustin M. Dermatology (DOI: 10.1159/000346641)
Background: The antifungal activity of coriander oil has already been demonstrated in vitro.
Objective: Evaluation of the efficacy and tolerability of 6% coriander oil in unguentum leniens in the treatment of interdigital tinea pedis.
Methods: Half-side comparative pilot study on subjects with symmetric, bilateral interdigital tinea pedis. Active drug and placebo control were applied twice daily on the affected areas, and follow-up visits were performed on days 14 and 28.
Results: 40 participants (mean age 52.5 years, 60% male) were included in the study. For 6% coriander oil in unguentum leniens, a highly significant improvement of the clinical signs (p < 0.0001) was observed during the entire observation period; the number of positive fungal cultures also tended to decrease (p = 0.0654). The tolerability of the tested substances was good.
Conclusion: Coriander oil is effective and well tolerated in the treatment of interdigital tinea pedis.
The active ingredient in coriander is coriandrol, which is a linalool.... which is a terpenoid (a documented sensitizer for allergic contact dermatitis). Wiki states: Linalool gradually breaks down when in contact with oxygen, forming an oxidized by-product that may cause allergic reactions...
Coriandrol – This form of Linalool is commonly found in plants. It is commonly found in Coriander seeds, which are used to produce essential oils. Palmarosa and sweet orange flowers are also common sources.
The Safety of Linalool Use
Linalool is generally safe. However, people with eczema have a 5-7% chance of having an adverse reaction if they come in contact with Linalool. The Linalool reacts with oxygen and exposure can cause an eczema flare up. The only way to stop the reaction is to minimize exposure to these products. While some individuals still enjoy using the products, it is important for them to prevent the linalool from oxidizing by buying smaller containers of products that contain linalool and replacing the lid after use.
The amount of linalool that is deadly for humans to ingest or place on the body has not been determined. It would probably be difficult for a sane individual to ingest or place on the body an amount that would prove fatal. Irrespective of this, linalool toxicity in humans who regularly use it has not yet been determined.