Role of dermicidin in tinea pedis

NewsBot · Jul 24, 2015

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Press Release
Tinea Pedis Update: Production of Protein Key in Control
July 23, 2015

New research shows that the protein dermcidin could play a key role in controlling athlete’s foot, Bryan C. Markinson, DPM, reported Thursday in his Plenary Lecture, “Tinea Pedis Update.”
“The body secretes dermcidin, which is toxic to fungi. The inability to produce this may trigger more infections,” said Dr. Markinson, who added that researchers are investigating methods to supplement the production of dermcidin. He is the chief of podiatric medicine and surgery at the Leni and Peter W. May Department of Orthopedic Surgery at Mount Sinai School of Medicine.
Dr. Markinson discussed advances in research of tinea pedis based on a review of non-podiatric literature published in the last four years. Those advances include the development of new treatments and questions about the effectiveness of laboratory tests in confirming tinea pedis.
Dermcidin is an antimicrobial peptide secreted by eccrine sweat glands. It has been found to inhibit the growth of T. rubrum, S. aureus, E. coli, E. faecalis, and C. albicans, he said. The most common micro-organisms found to cause tinea pedis are T. rubrum, T. interdigitale, and E. floccosum.
Other research showed that dermatomycosis infections, such as tinea pedis, are transmitted indirectly in infected scales, hair, nail pieces, the floor, shoe gear and insoles, and clothing. A study reported that microwave irradiation that reached temperatures of 50C–55C destroyed cell membranes and killed fungi in sponge insoles and cork insoles, Dr. Markinson said.
He also reported on the effectiveness of laboratory tests that used positive KOH and positive cultures to confirm the diagnosis of tinea pedis versus a clinical exam.
“Laboratory confirmation studies may not be all they are cracked up be,” Dr. Markinson said. “It may be that the gold standard of diagnosis should be what we see with our eyes.”
Conventional wisdom holds that a positive fungal culture is required for a definitive diagnosis of tinea pedis. Most studies require a positive culture, positive KOH, and clinical findings. In a pooled study of five similar studies for the diagnosis of tinea pedis, KOH specificity was 42.6 percent versus 77.7 percent for culture. Sensitivity was 73.3 percent for KOH, and 41.7 percent for culture.
“These are important findings for podiatrists because: one, most podiatrists do not do KOH preps; two, in the absence of a positive culture, in view of less sensitivity than KOH prep, and positive clinical findings, clinicians may fail to prescribe antifungal agents; and three, the presence of a negative KOH at screening may allow for earlier consideration of alternative diagnoses.”
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Admin2 · Jul 24, 2015

Dermcidin

Dermcidin is a protein with 110 amino acids that in humans is encoded by the DCD gene.^[3]^[4] The full-length protein produces derived peptides as proteolysis-inducing factor (PIF) and other anti-microbial peptides,^[4] secreted by human eccrine sweat glands onto the skin as a part of the innate host defense of the immune system. PIF is involved in muscular proteolysis.^[4]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161634 - Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Schittek B, Hipfel R, Sauer B, Bauer J, Kalbacher H, Stevanovic S, Schirle M, Schroeder K, Blin N, Meier F, Rassner G, Garbe C (Nov 2001). "Dermicidin: a novel human antibiotic peptide secreted by sweat glands". Nat Immunol. 2 (12): 1133–7. doi:10.1038/ni732. PMID 11694882. S2CID 26126901.

^ ^a ^b ^c "Entrez Gene: DCD dermicidin".

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