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Analysis of data on the treatment of 100 patients with purulent-necrotic forms of diabetic foot syndrome is presented. Patients were divided into two groups. In the first group (45 patients) treatment was conducted using traditional methods and techniques. In the second group (55 patients) during operation air-plasma cutting-coagulation device "Plazon" was used in NO-therapy mode. Nitric monoxide is known as multifunctional antioxidant substance, having great value in oxidative stress reactions. In the current study it was transported to the wound surface by air-flow of "Plazon" device. The condition of microcirculation in tissues was studied by computerized laser capillary flow analyzer "LAKK-01". It was shown that after removing inflammation in the healed wound, condition corresponding to characteristics of undamaged skin takes place in contrast to the patients from the group 1, where some asymmetry in the foot tissues microcirculation was shown as an evidence of functional and structural insufficiency of microcirculation system.