Welcome to the Podiatry Arena forums, for communication between foot health professionals about podiatry and related topics.
You are currently viewing our podiatry forum as a guest which gives you limited access to view all podiatry discussions and access our other features. By joining our free global community of Podiatrists and other interested foot health care professionals you will have access to post podiatry topics (answer and ask questions), communicate privately with other members (PM), upload content, view attachments, receive a weekly email update of new discussions, earn CPD points and access many other special features. Registered users do not get displayed the advertisments in posted messages. Registration is fast, simple and absolutely free so please, join our global Podiatry community today!
If you have any problems with the registration process or your account login, please contact contact us.
The Launch of Pfizer's Pregabalin and Eli Lilly's Duloxetine Will Improve Awareness of Diagnosis and Treatment Among Primary Care Practitioners
Quote:
WALTHAM, Mass., Nov. 17 /PRNewswire/ -- Decision Resources, Inc., one of
the world's leading research and advisory firms focusing on pharmaceutical and
health care issues, finds that the launch of more-expensive emerging agents
with regulatory approval for neuropathic pain will drive growth in the key
neuropathic pain markets. Market growth will reflect a shift in treatment
practices as physicians who historically relied on relatively inexpensive,
off-label generic therapies turn to more-expensive, approved drugs.
"Drug manufacturers are hoping to grab share in this growing market," said
Elana Feldman, analyst at Decision Resources. "After witnessing the success of
Pfizer's Neurontin, one of the only drugs currently approved for neuropathic
pain, companies are realizing that they can boost sales for products
traditionally indicated for other diseases by pursuing supplementary approval
for neuropathic pain."
The new Pharmacor study entitled Neuropathic Pain: Painful Diabetic
Neuropathy, Postherpetic Neuralgia, and HIV-Related Neuropathic Pain also
finds that Pfizer's antiepileptic drug pregabalin and Eli Lilly's
antidepressant duloxetine will improve awareness among physicians,
particularly primary care practitioners, of neuropathic pain diagnoses and
treatments. This awareness will lead to a steady increase in the number of
diagnosed and drug-treated neuropathic pain patients.
Neuragen RL is a proprietary natural medication for treating neuropathic pain by topical application.
Extensive use of Neuragen RL, including a controlled clinical trial, demonstrates its effectiveness as a topical analgesic which quickly relieves neuropathic pain in a variety of situations without harmful side effects. Most topical analgesics now on the market are useful for muscle aches and related inflammatory pain, but not for neuropathic pain – Neuragen RL helps for pain the others don’t touch. Neuragen RL does not numb the area of application and can be applied repeatedly. The key active ingredient of Neuragen RL is a purified variety of geranium oil, carefully isolated from years of clinical testing.
Has anyone has success using acupuncture for the treatment of painful peripheral neuropathy? I feel for patients who are already on multiple medications its a useful treatment option to offer before adding in yet another tablet.
Sandra
Sandra,you came upwith a good idea.Accupuncture is a good adjunct therapy which a lot of doctors(me included)underutilize.I am trying cymbalta for the pain-1 60 mg tablet q24h.I try the antiepileptics with fair results.I also go with capsaicin which is a topical analgesic derived from a hot pepper plant.This works by depleting substance P.
I also go with capsaicin which is a topical analgesic derived from a hot pepper plant.This works by depleting substance P.
my patients tell me they can only purchase this topically in WA in combination with topical glucosamine...a GP reportedly also told a patient it was available by prescription in WA either...anyone else has any luck getting it?
Neuragen RL is a proprietary natural medication for treating neuropathic pain by topical application.
Extensive use of Neuragen RL, including a controlled clinical trial, demonstrates its effectiveness as a topical analgesic which quickly relieves neuropathic pain in a variety of situations without harmful side effects. Most topical analgesics now on the market are useful for muscle aches and related inflammatory pain, but not for neuropathic pain – Neuragen RL helps for pain the others don’t touch. Neuragen RL does not numb the area of application and can be applied repeatedly. The key active ingredient of Neuragen RL is a purified variety of geranium oil, carefully isolated from years of clinical testing.
Today I had a fellow with a severely painful case of diabetic neuropathy.I wanted to start him on cymbalta.Then I saw that his liver enzymes(SGOT and SGPT) were markedly elevated.I did not put him on that.Be careful regarding the newer meds with people with liver problems.
Accupuncture can be a very useful therapy for people who have "gone through the mill" regarding treatments for diabetic neuropathy.It seems that this is a very trying malady to treat.
I know some cases of accupuncture and accupressure helping difficult neuropathic pain. I also have experience with a Dr. Lee at LSU's Pennington Biomedical Research Institute/ Neuromedical Center in Baton Rouge, LA. He has a study and treatment program using Tai-Chi for treatment of neuropathic pain. I have a few patients who have benefitted from this Tai-Chi program. -John
Sorry, this appears to be an old discussion--
Still relevant, though. Neuropathy is difficult to treat successfully.
__________________
Dr. John G. Fasick
LSUHSC New Orleans
Clinical Insructor, LSU School of Medicine jfasic@lsuhsc.edu
Last edited by Gibby : 6th February 2009 at 06:47 AM.
Reason: old thread
Press Release: Phase II Results For GSK1838262 (XP13512) Reported For Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
29 Apr 2009
Quote:
GlaxoSmithKline (NYSE:GSK) and XenoPort, Inc. (Nasdaq:XNPT) announced results from a Phase II clinical trial of GSK1838262/XP13512 (gabapentin enacarbil) for neuropathic pain associated with diabetic peripheral neuropathy (DPN) in adults. GSK1838262 did not demonstrate a statistically significant improvement on the primary endpoint when compared to placebo, based on the change from baseline to end of treatment on the Pain Intensity-Numerical Rating Scale (PI-NRS). The pregabalin active control arm also did not differentiate from placebo on this same endpoint. The failure of the study to demonstrate a statistically significant benefit on the primary endpoint may be a consequence of the unexpectedly high placebo response rate observed in the study.
This 14-week, double-blind, placebo-controlled study enrolled 421 patients who were diagnosed with either Type 1 or Type 2 diabetes mellitus with signs and symptoms of DPN. Patients were randomized to receive either 1200 mg/day, 2400 mg/day or 3600 mg/day of GSK1838262 administered in divided doses twice daily, 300 mg/day of pregabalin as an active control, administered in divided doses three times daily, or placebo.
Throughout the study, GSK1838262 was generally well tolerated; the two most frequently reported adverse events were dizziness and somnolence.
"Although we are disappointed that neither GSK1838262 nor pregabalin demonstrated a clear clinical benefit over placebo in this study, we will be evaluating the study results further in order to determine our next steps," said Atul Pande, M.D., senior vice president, GlaxoSmithKline Neurosciences Medicines Development Center.
Ronald W. Barrett, Ph.D., chief executive officer of XenoPort, stated, "A high placebo response is not uncommon in DPN studies, and this has been a contributing factor to several failed studies testing different drugs in this patient population. The failure of pregabalin in this study makes it difficult to draw definitive conclusions about the efficacy of GSK1838262. We are encouraged by the observation that all doses of GSK1838262 were generally well tolerated, particularly since the 3600 mg dose represents the highest dose tested in a study of this length."
GSK1838262 is a new chemical entity that is designed to improve upon the pharmacokinetics of gabapentin by taking advantage of high-capacity transport mechanisms in the gastrointestinal tract to improve absorption.
I know a rehab/occupational physician who does a lot of work with long term pain. He recommends use of "goanna" ointment, which is a non-prescription analgesic cream that has a fair dose of capsaicin in it. A cheaper way to access whatever benefit capsaicin can provide.
regards Phill
I have been using Acupuncture for Diabetic and non-Diabetic neuropathy. After the 1st session in most cases there has been some change. Within 3 sessions there has been significant change in the pain and less numbness reported as well.
There are 5 points in the foot and 3 on the leg that I find useful, only using these one leg only - this affects both legs though.
Is there anyone else who is having some success with Acupuncture?
New drugs for neuropathic pain
Size of study group
Linear Mode
