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Probe-to-Bone Test for Diagnosing Diabetic Foot Osteomyelitis

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  #1  
Old 26th January 2007, 06:29 PM
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Default Probe-to-Bone Test for Diagnosing Diabetic Foot Osteomyelitis

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Probe-to-Bone Test for Diagnosing Diabetic Foot Osteomyelitis
Reliable or relic?

Lawrence A. Lavery, David G. Armstrong, Edgar J.G. Peters and Benjamin A. Lipsky
Diabetes Care 30:270-274, 2007
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OBJECTIVE—We sought to assess the accuracy of the probe-to-bone (PTB) test in diagnosing foot osteomyelitis in a cohort of diabetic patients with bone culture proven disease.

RESEARCH DESIGN AND METHODS—In this 2-year longitudinal cohort study, we enrolled 1,666 consecutive diabetic individuals who underwent an initial standardized detailed foot assessment, followed by examinations at regular intervals. Patients were instructed to immediately come to the foot clinic if they developed a lower-extremity complication. For all patients with a lower-extremity wound, we compared the results of the PTB test with those of a culture of the affected bone. We called PTB positive if the bone or joint was palpable and defined osteomyelitis as a positive bone culture.

RESULTS—Over a mean of 27.2 months of follow-up, 247 patients developed a foot wound and 151 developed 199 foot infections. Osteomyelitis was found in 30 patients: 12% of those with a foot wound and 20% in those with a foot infection. When all wounds were considered, the PTB test was highly sensitive (0.87) and specific (0.91); the positive predictive value was only 0.57, but the negative predictive value was 0.98.

CONCLUSIONS—The PTB test, when used in a population of diabetic patients with a foot wound among whom the prevalence of osteomyelitis was 12%, had a relatively low positive predictive value, but a negative test may exclude the diagnosis.
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  #2  
Old 26th January 2007, 06:38 PM
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Default Re: Probe-to-Bone Test for Diagnosing Diabetic Foot Osteomyelitis

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Old 5th February 2007, 07:51 PM
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Default Re: Probe-to-Bone Test for Diagnosing Diabetic Foot Osteomyelitis

The initial probe to bone data was based on a population group that had extremely high likelihood of having osteomyelitis - it was not meant to suggest that if you can probe to bone it is osteomyelitis. However, if you think that there is a high index suspicion that osteomyelitis is present and you can probe to bone, then there is a greater chance that you are right. Higher index of suspician = longer duration of wound, previous history of infection etc...

The interpretation of the initial study results has changed over the years - deviating from the original authors conclusion, simply because other authors citing this work have interpreted the results in different ways - I know that a lot of practitioners think that osteomyelitis is present as soon as bone is exposed, when it may not be the case. It makes you think about checking where people got their initial information from to make sure their interpretation is appropriate.....just a thought....
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