Re: contraindications between methotrexate and phenol (nail surgery)
Methotrexate is a folic acid analogue and is (amongst other features) a potent inhibitor of some types of immune response.
It is not a contra-indication to nail surgery per se, but because of the healing period following phenolisation, you should consider an incisional technique. I cannot do better than to quote from Goodman & Gillman:
"It is imperative that a skilled medical team and sophisticated facilities, particularly abundant platelet transfusions and measures for preventing and combating infections, be available to provide the intense supportive therapy necessary to control the severe toxic manifestations that may result when intensive dosage schedules are used"
In other words, much depends on the current situation, the current health of the patient, and it would most certainly be wise to have a chat to the consultant in charge of the case, or better still outline your concerns in a letter.
All the best