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Topical Insulin Accelerates Diabetic Wound Healing

Discussion in 'Diabetic Foot & Wound Management' started by NewsBot, May 30, 2012.

  1. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1

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    Topical Insulin Accelerates Wound Healing in Diabetes by Enhancing the AKT and ERK Pathways: A Double-Blind Placebo-Controlled Clinical Trial
    Maria H. M. Lima, et al
    PLoS ONE 7(5): e36974. doi:10.1371/journal.pone.0036974

     
  2. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Insulin treatment directly restores neutrophil phagocytosis and bactericidal activity in diabetic mice, thereby improving surgical site infection with Staphylococcus aureus
    Hidekazu Yano et al
    Infection and Immunity October 2012
     
  3. davidh

    davidh Podiatry Arena Veteran

    Interesting, but with only 22 subjects (if I'm reading this right) inconclusive.
     
  4. Paul Bowles

    Paul Bowles Well-Known Member

    The number alone doesnt indicate statistical significance. So why inconclusive?
     
  5. davidh

    davidh Podiatry Arena Veteran

    Hi Paul,

    My reasoning is that this is not a representative sample.
    It's an unrepresentative sample which has then been subject to statistical analysis.

    Also, if you read the study there seems to have been a few drop-outs on the way.
    It's what would have been called a pilot study back in the day when I did a research project for my undergrad degree.
    It may point the way forward for more research, but on it's own it can not be considered conclusive.
     
  6. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    This clinical trial is completed, but was only just registered:

    Intensive Insulin Treatment and Ischemic Foot Ulcer
     
  7. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Topical Application of Insulin Accelerates Vessel Maturation of Wounds by Regulating Angiopoietin-1 in Diabetic Mice
    Chaofei Li et al
    International Journal of Lower Extremity Wounds December 2015 vol. 14 no. 4 353-364
     
  8. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effect of local insulin injection on wound vascularization in patients with diabetic foot ulcer.
    Zhang Z, Lv L.
    Exp Ther Med. 2016 Feb;11(2):397-402
     
  9. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Insulin pump for the treatment of diabetes in combination with ulcerative foot infections.
    Fan HJ et al
    J Biol Regul Homeost Agents. 2016 Apr-Jun;30(2):465-70.
     
  10. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effects of insulin on the skin: possible healing benefits for diabetic foot ulcers.
    Emanuelli T et al
    Arch Dermatol Res. 2016 Sep 21.
     
  11. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effect of Systemic Insulin Treatment on Diabetic Wound Healing.
    Vatankhah N et al
    Wound Repair Regen. 2017 Jan 24. doi: 10.1111/wrr.12514
     
  12. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effect of Using Topical Insulin on Improving Pressure Ulcers
    Healing Among Neurological Patients

    Dalia Masoud El-said et al
    IOSR Journal of Nursing and Health Science (IOSR-JNHS)
    e-ISSN: 2320–1959.p- ISSN: 2320–1940 Volume 6, Issue 6 Ver. III. (Nov.- Dec .2017), PP 80-85

     
  13. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effectiveness of topical insulin in the management of diabetic foot ulcers.
    Shafaatullah, Iqbal S, Zulfiqar B, Zufishan S.
    Professional Med J 2019;26(9):1487-1490.
     
  14. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effectiveness of Topical Insulin Dressings in Management of Diabetic Foot Ulcers.
    Bhittani MK et al
    World J Surg. 2019 Dec 9
     
  15. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    A study of effectiveness of topical insulin on healing of diabetic ulcers at tertiary health care centre: a cross sectional study from Puducherry
    Paritoshsingh B. Thakur et al
    Thakur PB et al. Int Surg J. 2020 March;7(3):xxx-xxx
     
  16. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences
    Jiao Wang and Jixiong Xu
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
     
  17. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
  18. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Topical Insulin and Normal Saline in Chronic Diabetic Foot Ulcers- A Prospective Analytical Study.
    Journal of Clinical & Diagnostic Research . Aug2020, Vol. 14 Issue 8, p11-13. 3p.
    BIRADAR, DAYANAND; PATIL, MALLIKARJUN B.; BALOORKAR, RAMAKANTH; SINDAGIKAR, VIKRAM; MANOOP, K.
     
  19. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Topical insulin and normal saline in chronic diabetic foot ulcers- A Prospective comparative study
    Dayanand Biradar
    Year : 2020 | Volume : 5 | Issue : 3 | Page : 51-52
     
  20. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
  21. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    fficacy of topical application of insulin versus
    platelet rich plasma versus normal saline
    dressings in the healing of diabetic foot ulcers: A
    study from a tertiary care center in India

    Vikash Katiar et al
    Source
     
  22. Stanley

    Stanley Well-Known Member

    I used to mix testosterone with insulin and triple antibiotic powder in men. I stopped when they changed the class of testosterone. In older women, I would use estrogen cream mixed with insulin and antibiotic powder.
     
  23. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    The Efficacy of Local Insulin Versus Topical Phenytoin or Normal Saline in Diabetic Foot Ulcer Management: A Prospective Comparative Study
    Jamuna Nagaraj, Venkatesh Subbiah
    Cureus. 2022 Oct 19;14(10)
     
  24. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Study of effects of topical insulin in wounds of diabetic patients
    Mohak Jain et al
    Source
     
  25. NewsBot

    NewsBot The Admin that posts the news.

    Articles:
    1
    Insulin Can Delay Neutrophil Extracellular Trap Formation In Vitro-Implication for Diabetic Wound Care?
    Caren Linnemann et al
    Biology (Basel). 2023 Aug 3;12(8):1082
     
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