Trichloroacetic acid for Verrucae

NewsBot · Jun 25, 2014

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An open, comparative clinical study on the efficacy and safety of 10% trichloroacetic acid, 25% trichloroacetic acid and cryotherapy for verruca plana
Fatma Pelin Cengiz and Nazan Emiroglu
Cutaneous and Ocular Toxicology; Posted online on June 18, 2014

Objective: Although there are several methods to treat Verruca plana, warts do not respond well to the common therapeutic options. In this study, we compared the safety and efficacy of 10% trichloroacetic acid, 25% trichloroacetic acid, and cryotherapy for the treatment of warts caused by Verruca plana.

Methods: Ten percent and 25% trichloroacetic acid were applied to warts weekly until all lesions cleared. Cryotherapy was performed by liquid nitrogen spray for 5–10 seconds for each lesion per week until the lesions cleared. The number of Verruca plana lesions and adverse effects were evaluated five times during the treatment (the initial visit, week 2, week 4, week 6, and week 8).

Results: The number of lesions decreased through week 8 for all three treatments, and the reductions in the mean numbers of lesions were statistically similar (p > 0.05). Those in the cryotherapy group exhibited more erythema, pain, erosions, bullae, and hyperpigmentation (p < 0.001, p < 0.001, p < 0.001, p < 0.05, and p = 0.001, respectively) than those in either TCA group. Itching was more common among those in the trichloroacetic acid groups than in the cryotherapy group (p < 0.05). Additionally, hyperpigmentation, erythema, pain, and itching were more frequent in the 25% trichloroacetic acid group than in the 10% trichloroacetic acid group (p < 0.001), (p < 0.05), (p < 0.05), (p < 0.05).

Conclusion: Ten percent trichloroacetic acid, 25% trichloroacetic acid, and cryotherapy are effective methods to treat Verruca plana. 10% trichloroacetic acid offers a safer and easier treatment than either 25% trichloroacetic acid or cryotherapy.
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Read More: http://informahealthcare.com/doi/abs/10.3109/15569527.2014.924961

Admin2 · Jun 25, 2014

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NewsBot · Apr 9, 2016

Effectiveness and safety profile of 40% trichloroacetic acid and cryotherapy for plantar warts
Fatma Pelin Cengiz, Nazan Emiroglu, Ozlem Su and Nahide Onsun
The Journal of Dermatology; Early View

Plantar warts are one of the most common infectious skin disease caused by the human papillomavirus. In this study, cryotherapy with liquid nitrogen delivered by the physician, up to four treatments 2 weeks apart. Forty percent trichloroacetic acid (TCA) was applied to warts weekly up to four treatments. At the end of 4 weeks, the clinical improvement of the TCA group (n = 30) was six patients (20%) with no change, one patient (3.3%) with a mild response, 13 patients (43.3%) with a moderate response and 10 patients (33.3%) with a good response. In the cryotherapy group, clinical responses were 12 patients (40%) with no change, four patients (13.3%) with a mild response, 12 patients (40%) with a moderate response and two patients (6.7%) with a good response. There was a statistically significant difference in improvement between the two treatment groups (P = 0.027). According to our results, TCA 40% is more effective for clearance of plantar warts with significantly improved long-term safety profile.
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NewsBot · May 13, 2020

Comparison of 40% trichloroacetic acid and cryotherapy for the treatment of plantar warts; a single-blind, randomized clinical trial.
Karrabi M et al
Dermatol Ther. 2020 May 12

BACKGROUND:
Plantar warts can cause pain near the toes and the sole of the foot and may result in referral for treatment. This study was aimed at comparing 40% trichloroacetic acid (TCA) and cryotherapy (Cryo) for the treatment of plantar warts.

METHODS:
This single-blind, randomized clinical trial was performed on 60 subjects presenting with plantar wart in Sabzevar, Iran in 2018. The first intervention group was treated with 40% TCA in four sessions within four weeks. The second intervention group was treated with Cryo using liquid nitrogen in four sessions within eight weeks.

RESULTS:
The mean (SD) age of subjects was 20.16 ± 5.96 years and 68.33% (n=41) were male. Although the resolution rate of warts in the TCA 40% group was greater than the Cryo group, there was no statistical association found between the two groups by adjusting age, sex, and basal time (P = 0.648).

CONCLUSION:
Findings suggest that although 40% TCA was almost as effective as Cryo in the treatment of plantar warts, considering the lower adverse effects of TCA 40% group as compared to the Cryo group, it could be a proper alternative.
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Trichloroacetic acid for Verrucae

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Trichloroacetic acid for Verrucae

NewsBot The Admin that posts the news.

Admin2 Administrator Staff Member

NewsBot The Admin that posts the news.

NewsBot The Admin that posts the news.

Experience treating Verrucae pedis with Salycilic Acid and Trichloroacetic acid

Trichloroacetic acid vs needling for stubborn vp treatment

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Trichloroacetic acid crystals?

Tranexamic Acid Utilization in Foot and Ankle Surgery

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Role of an acidic environment in the treatment of diabetic foot infections

Share This Page

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