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GW Pharmaceuticals announced preliminary results of two Phase III studies of Sativex®, its cannabinoid spray medicine, in peripheral neuropathic pain.
The results of the study in patients with neuropathic pain characterized by allodynia show that patients taking Sativex obtain clinically important improvements in their management of pain and quality of sleep. In comparison with placebo, statistically significant improvements were seen for key outcome measures, including a positive result in the primary analysis of patient response, the outcome measure recommended by regulatory authorities.
The results of the study in patients with painful diabetic neuropathy show that patients taking Sativex obtained substantial improvements in their pain, indeed among the highest level of response seen in the published literature. There was an abnormally large placebo response in this study, which means that the data are more difficult to interpret categorically.
Dr Stephen Wright, GW’s R&D Director, said, “Neuropathic pain is one of the most difficult types of chronic pain to treat. These studies focused on particularly high need patients, who were already taking the best available pain treatments, and yet still suffered severe pain. Even in this most difficult to treat population, Sativex has produced improvements over and above current treatments that are highly meaningful to the everyday lives of patients.”
This multi-centre double-blind, randomized, placebo-controlled parallel group study in 297 patients examined the effect of Sativex in patients with painful diabetic neuropathy. Patients in this study were being treated with a range of currently available analgesics, which were maintained during the course of the study.
In this study, patients taking Sativex showed a 30% mean improvement in pain scores, among the highest level of response seen in the published literature. One third of Sativex patients achieved over a 50% improvement in pain.
Sativex is approved and marketed in Canada for the symptomatic relief of central neuropathic pain in MS, and is the subject of an ongoing regulatory submission in Canada for the relief of cancer
Unfortunately the active cannabinoids that give the 'high' have been removed from Sativex, Robert, so I'd stick with your home-grown variety for now. Interestingly, I had a 83 y/o great grandmother in surgery last week who grows her own plants then harvests the buds to make a variety of foods - stews, soups, chocolates and cakes. She also adds them to vodka which she has as her 'night-cap' and swears by the medicinal effect. In a previous life she was a General Practitioner and magistrate. Not the first time I've come across an octogenerian dope fiend either.
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"citing an indisposition due to special circumstances"
Interestingly, I had a 83 y/o great grandmother in surgery last week who grows her own plants then harvests the buds to make a variety of foods - stews, soups, chocolates and cakes. She also adds them to vodka which she has as her 'night-cap' and swears by the medicinal effect. In a previous life she was a General Practitioner and magistrate. Not the first time I've come across an octogenerian dope fiend either.
Agreed! Manys the home visit i've done with some dignified silver haired little love and seen assorted cannibis smoking equipment lying around. One even sparked up while i was treating her.
It is truly observed that every generation thinks THEY invented all the interesting vices.
Manys the home visit I've done with some dignified silver haired little love and seen assorted cannabis smoking equipment lying around. One even sparked up while i was treating her.
Nice one, but did she offer you a puff?
Quote:
It is truly observed that every generation thinks THEY invented all the interesting vices.
The folly of youth. They usually get a shock when they discover the pile of dirty magazines and smoking appareil underneath Grandpa's bed.
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"citing an indisposition due to special circumstances"
Cannabinoid Spray Improves Neuropathic Pain
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